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Diagnosis by prick test with purified Alt a 1 allergen
The wheal areas obtained with Alt a 1 protein are significantly greater than with extract of total Alternaria alternata and extract without Alt a 1.
Alt a 1 is recommended for diagnosis and treatment of Alternaria alternata-sensitised patients. The major Alternaria alternata allergen is responsible for sensitisation of >90% of the allergic population.
Characteristics of purified Alt a 1
Specific sIgE serum levels vs. Alt a 1 in the three treatment groups (mean ± SEM)
Specific sIgG4 serum levels in Alt a 1 in the three treatment groups (median ± SEM)
Alt a 1 is a safe treatment with a high level of tolerance; only mild or moderate adverse events were seen. No serious adverse events were reported. Previous clinical trials showed the same safety pattern.